12. Christina Applegate – Multiple Sclerosis
Christina Applegate received her multiple sclerosis diagnosis in 2021 after noticing symptoms during the filming ofDead to Me. The disease has brought mobility issues, fatigue, and sensory problems that make everyday tasks difficult, yet she completed the final season of her hit show despite the challenges.
She has spoken candidly about the emotional toll while advocating for early detection and support for those living with MS. Her continued work in television shows the strength of refusing to let the illness define her identity or stop her creative drive.
